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*Correspondence: Raffaela Maione, [email protected] ORCID: Raffaela Maione, orcid.org/0009-0002-0491-2018 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Besides the main differential characteristics, other negative findings to rule out common causes of true TMA, such as TTP, HUS, DIC, drug-induced TMA, autoimmune-associated TMA, etc., are also essential to guide primary specific management

Malabsorption Issues: Conditions like Crohns disease or celiac disease can impair absorption, making injections necessary