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TRPV1 (Transient Receptor Potential channels) and TRPA1 ion channels on sensory nerve endings are upregulated, meaning that chemical stimuli that would be imperceptible on healthy skin trigger pain signaling and neurogenic inflammation in rosacea skin

Abnormally high concentrations of Cu have been found in the striatum in patients with HD and in mouse models of HD

Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees

In the context of oral cancer, curcumin has been studied in laboratory models, and early-phase clinical trials have explored its effects either as a chemopreventive or as an adjuvant to therapy