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Natl Sci Rev 11:nwae182

More recently, secretase (asparagine endopeptidase) has been identified as a key enzymatic contributor to this process [26]

These brainstem nuclei are key for the detection of inflammatory stimuli, and project higher in the brain, namely on the PVN ( paraventricular nucleus ) of the hypothalamus (252) and on the amygdala (253)