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Frosty container, placed at 80 C overnight to complete cryopreservation, and submitted to Active Motif for ATAC-sequencing

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Therefore, a decrease in xCT inhibits the intracellular import of cysteine, leading to less glutathione synthesis, lower GPX4 activity, and ultimately the accumulation of lipid hydroperoxides, which is linked to loss of plasma membrane integrity 35