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Microscopy experiments on a 3D spheroid model of MYCN-driven NB support this hypothesis

In PCa tissues, AR expression is significantly upregulated [24]

2006 Sep-Oct;9(5):311-6

To test if the alanine substitutions in A2 helix in cyclin D2 and D3 also disrupt helix-based docking, we performed in vitro kinase assays with the full length Rb and compared the wild type with A2 helix mutant versions of cyclin D2 and D3