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Kisli M, Sacmaci H

The safety results in children under 3 years was similar to the therapys known safety profile

Notably, the knockdown of ZDHHC11 led to a reduction in S-palmitoylation of ATG2A, which could be reversed by re-expressing wild-type ZDHHC11 but not the palmitoyltransferase-deficient variant ZDHHC11-C155S (Liu et al, 2018) (Figs