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A meta-analysis of 18 clinical trials involving 1,883 women with poor ovarian response undergoing IVF or intracytoplasmic sperm injection found supplementing with 75 mg DHEA daily for two to four months reduced the risk of miscarriage by 50%, increased the pregnancy rate by 53%, and increased successful births by 87%

It was shown that BDMC significantly reduced the levels of pro-inflammatory cytokines IL-6, IL-1, TNF-, and MCP-1 in LPS-induced RAW264.7 cells and that this anti-inflammatory effect is associated with inhibition of the activation of the PI3K/Akt signaling pathway ( Siraitia grosvenorii (Swingle) A.M.Lu and Z.Y.Zhang (Luohanguo) exerts an anti-inflammatory effect in the treatment of UC by modulating the AMPK-PI3K/Akt/mTOR signaling pathway

Paolicchi, A., M

Larger randomized trials are underway