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doi: 10.4162/nrp.2012.6.3.221 133 MarreiroDNGelonezeBTambasciaMALerrioACHalpernACozzolinoSM

As a vital constituent of antigen-presenting cells (APCs), macrophage possesses two exact opposite-in-function phenotypes, M1 and M2, the former polarized by lipopolysaccharide (LPS), producing pro-inflammatory cytokines such as IL-1, IL-6, IL-12, IL-23, and TNF-, the latter polarized by Th2 cytokines, producing anti-inflammatory cytokines such as IL-10 and TGF- [20]

For instance, protein thiols can be modified through: S -nitrosylation, S -glutathionylation, S -succinylation, ADP-ribosylation, disulfide (including mixed disulfide bonds with glutathione), sulfenic acid, sulfinic acid, sulfonic acid, and Cys-adducts (with electrophilic MDMA metabolites), which cannot be reduced by DTT/Fe +2 ferrous iron) [80]

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