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Histopathological evaluation using H&E staining (Figure 11A) revealed that neurons in the Ischemia-Reperfusion group were disorganized, exhibited contracted and irregular cell bodies, and displayed pyknotic nuclei with indistinct structural features

When cells are exposed to oxidative stress, the conformation of Keap1 changes, allowing Nrf2 to stabilize and translocate into the nucleus, where it activates the expression of a series of antioxidant genes 28

Further studies are required to provide more evidence about the differences between RBC senescence and eryptosis

Figure 1 ) was generally used as an adjunct to standard medical therapy, not in place of it