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2022 Mar 3;14(5):1076

[223] Symptoms of melatonin overdose may include excessive drowsiness, confusion, headache, nausea, and difficulty waking up the following morning

Author: Yuzhao Huang, Yuchen He , Meagan J

Additionally, the results of clinical studies of Nrf2 activators in neurodegenerative diseases have been inconsistent, most likely because of genetic differences between individuals (e.g., NLRP3 or NFE2L2), the stage of the disease at intervention, and the differences between the complex pathology of human PD and toxin-based animal models