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it can be catabolized by ACE into the biologically inactive pentapeptide, Ang-(15), or by aminopeptidases into inactive fragments

In the absence of reliable tumor markers or imaging technologies for early detection of precursor lesions, it seems prudent to consider gonadal biopsies to exclude the presence of germ cell neoplasia in situ or gonadoblastoma in most individuals with 46,XY or 45,X/46,XY DSD with retained gonads

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Together, the hydrophilic and lipophilic results revealed a group of compounds that characterized the brain metabolic differences between Tbx1 +/ and WT mice (Fig 2AC)