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Gut microbial-derived SCFAs can play a crucial role in anti-inflammatory actions through direct and indirect mechanisms, as they maintain gutbrain permeability and sustain inputs to the CNS to maintain microglia homeostasis (209)

Viral hepatitis serologies and autoantibodies were nonreactive

Preclinical investigations encompassing ethanol-induced gastric mucosal lesions, NSAID-mediated ulceration, cysteamine-induced duodenal injury, and inflammatory bowel disease analogues have reported associations between BPC157 exposure and reductions in mucosal lesion surface area, preservation of submucosal vascular architecture, and modulation of mucosal structural integrity

Animals receiving BPC-157 showed significantly better collagen fiber organization, higher biomechanical tendon strength, and faster attachment reintegration compared to controls