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regulating calcium signaling 49 , stimulating extracellular vesicle release and endocytosis 50 , and is even involved with learning and memory formation through its activation of CREB 51 and retrograde transmission from the post- to pre-synaptic terminal, stimulating neurotransmitter release and long-term potentiation 52

Attention to other side effects induced by mitochondrial-targeted therapy is warranted

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