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This depends on the diagnosis

Ricciardi BR, Saunders JB, Williams R, Hopkinson DA

Because B12 and all other B vitamins are water-soluble, if you end up taking too much, they are easily eliminated in the urine

Compared to other clusters, patients of this group exhibited lower average severity across almost all symptoms and comorbidities, including low rates of POTS (4.0% as a symptom and 15.3% as a comorbidity)