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Studies indicate that exposure to PS-NPs significantly downregulates dopamine levels in zebrafish (Ren et al., 2024), mechanistically linked to MPs-triggered neuroinflammation that inhibits tyrosine hydroxylase, a key enzyme in dopamine synthesis (Wang et al., 2025)

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Changes in gut microbiota have been linked to several neurological conditions such as autism, anxiety, depression, schizophrenia, migraine, and neurodegeneration (Mohajeri et al., 2018