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Firstly, during the inflammatory phase, bFGF stimulates the proliferation and differentiation of vascular endothelial cells to foster neovascularization

Jelic MD, Mandic AD, Maricic SM, Srdjenovic BU (2021) Oxidative stress and its role in cancer

Earlier studies have described that IL-17A induces platelet aggregation and activation, regulates the release of NETs to enhance neutrophil infiltration, and promotes deep vein thrombosis (229)

Thus, our data establish RUNX2 as a molecular sensor of the osteoblast REDOX environment and mechanistically clarify how ROS negatively impacts osteoblast differentiation and bone formation