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Interestingly, the same Abdeg was shown to improve radioimaging by shortening the in vivo plasma half-life of a radioactively labeled, tumor-specific human IgG1 mAb in mice, resulting in reduced systemic exposure and thereby improving the imaging contrast in positron emission tomography [121]

However, chronic use or high doses may require a longer recovery period and more focused nutritional support

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Notably, exogenous serine supplementation failed to rescue the GSH level in inflammatory macrophages with PHGDH inhibition (Fig