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In addition, preclinical trials showed that after an initial response of xenograft model of hepatocellular carcinoma to sorafenib (a multi-kinase inhibitor with antiangiogenic properties), the tumour progressed within a month due to the large-scale co-option of sinusoidal and portal tract vessels [54]

Clinical Evidence to Date To date, no randomized controlled trials (RCTs) have specifically evaluated the impact of GLP-1RAs on AITD

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Joints where the ribs and spine attach can become stiff, which may limit chest and lung expansion