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5-Amino-1MQ vs AOD-9604: Key Takeaways 5-Amino-1MQ and AOD-9604 are both powerful fat-loss agents but their strengths come from entirely different mechanisms: 5-Amino-1MQ Inhibits NNMT to preserve NAD, activate SIRT1, elevate basal metabolic rate, and improve metabolic flexibility (Kraus et al., Nature Medicine )