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Evans, R.M., Swanson, L., Rosenfeld, M.G

In homozygous LDLR mutant mice, it was shown in vivo that AAV-CRISPR/Cas9-mediated gene editing to correct the LDLR mutation resulted in decreased atherosclerosis and macrophage infiltration compared with placebo, as well as significant reductions in serum total cholesterol, LDL-C, and TG

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