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STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient

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Experimental models demonstrate that MNPs exposure leads to increased apoptosis, granulosa cell dysfunction, disruption of estrous cyclicity, and impaired ovarian development ( Together, these findings underscore the critical role of modifiable environmental and behavioral exposures in shaping the trajectory of ovarian aging and reproductive lifespan

After host cell entry, the ORF9b of SARS-CoV-2 RNA could directly manipulate mitochondrial function to evade host cell immunity, facilitate viral replication and trigger the onset of COVID-19