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Wei Y, Wang Z, Liu Y, Liao B, Zong Y, Shi Y, et al

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10.3390/ijms25169061 169 ParkD.JeongH.LeeM

EZH2-mediated H3K27me3 methylation (requiring SAM) at the promoters of senescence-promoting genes keeps those genes silenced while SIRT1 and FOXO3 activate longevity-promoting gene sets