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To achieve early diagnosis and overall management of PD, key techniques and challenges include constructing a clinical database, bolstering PD early biomarker research, interpreting the clinical significance of biomarkers, enhancing interdisciplinary collaboration, establishing a joint diagnosis and AI diagnostic system using multiple biomarkers, as well as setting up a one-stop diagnostic and treatment center in partnership with community-based health service centers to screen, manage, and educate the high-risk PD populations

doi: 10.1016/j.immuni.2016.02.023 29 GreenbaumUStratiPSalibaRMTorresJRondonGNietoYet al

Deficiency of hepatocystin induces autophagy through an Mtor-dependent pathway

Quantitative metabolite profiling typically comes after qualitative profiling because the understanding of how much is often as important as what is it, especially as the drug makes its way along the discovery and development path