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demonstrated that CBS could function as a participant in resistance to ferroptosis induced by erastin, which is transcriptionally upregulated by NRF2 [76]

It is present in SOD, a vital antioxidant enzyme that converts the singlet oxygen radical into hydrogen peroxide

Under the synergistic stress of ROS accumulation and Ca 2+ overload, this condition eventually induces sustained opening of the mitochondrial permeability transition pore (mPTP) ( Pathological opening of the mitochondrial permeability transition pore (mPTP) promotes the release of pro-apoptotic molecules such as cytochrome c (Cyt C) and Smac/DIABLO into the cytosol, thereby initiating the caspase-9mediated intrinsic apoptotic cascade and triggering cardiomyocyte death (Zorov et al., 2014)