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Within hours after cleaning, teeth become coated with a layer of salivary proteins, which can isolate antibacterial materials from bacteria, thereby reducing antimicrobial efficiency and long-term efficacy ( In addition to the two aforementioned oral-specific environmental resistance factors, the clinical translation of nanomaterials currently faces several challenges:(1) the long-term biosafety, biocompatibility, and functional durability of these nanomaterials within the oral cavity require rigorous assessment in live animal models and, ultimately, clinical trials ( in vitro

doi: 10.1093/humupd/dmx022 4 BaratiENikzadHKarimianM

It is now, however, recognized that approximately 20% of patients with bronchiectasis also have significantly elevated sputum eosinophils and Th2 markers ( Figure 2 )

Its incidence is relatively low, but only a part of patients could survive for more than 1 month, and most of them suffer from disability (Feigin et al., 2009