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Prez-Page M, Yu E, Li J, et al

During ferroptosis, mitochondria not only act as a site for lipid peroxidation but also function as a central hub amplifying death signals ( 4.4 P53 as a bi-functional gatekeeper The tumor suppressor p53 is a pivotal modulator of both ferroptosis and cuproptosis

The influence of the tumor microenvironment on metabolic adaptations cannot be ignored, as it plays a critical role in shaping cellular responses and therapeutic outcomes