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The same external stimulus, like UV light, will drive different levels of inflammation and oxidative stress depending on tissue context

In clinical trials, BH4 treatment improved specific autistic symptoms in children including adaptability, verbal expression, social responsiveness and interactions, communication, cognitive abilities, hyperactivity, and inappropriate speech [19, 20, 21, 22, 23]

[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Granell R., Heron J., Lewis S., Davey Smith G., Sterne J.A.C., Henderson J

Consistent with this, we demonstrate that treatment with MK-801, even at doses that do not evoke weight loss, elicits pronounced hyperthermia in DIO mice (Extended Data Fig