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Mechanistically, SSP intermediates couple to the TCA cycle, where PSAT1 catalyzes the conversion of 3-PHP to PS while simultaneously converting GLU to -KG, thereby channeling GLU-derived carbon into the TCA flux (58)

However, P53 was also reported to repress ferroptosis by combining with dipeptidyl peptidase-4, which could interact with NOX1 on cellular membrane and lead to lipid peroxidation without P53 (98)

In the infected fly gut, ROS was produced from the NADPH oxidase (DUOX) protein of epithelial cells, which is triggered by invading bacteria [32]

Volatiles were then evaporated under reduced pressure and the crude residue was dry-loaded and purified by chromatography on silica gel (DCM/MeOH gradient from 99:1 to 85:15) to afford 809 mg (83%) of title compound as a white solid