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GSH dysfunction not only impairs GPX4 activity but also mobilizes intracellular Fe 2 + , thereby accelerating lipid peroxidation and ferroptotic death 131,132

Secondly, it was found that dietary Se intake was weakly correlated with peripheral Se levels such as whole blood and serum (84), and the intake of Se did not accurately reflect the relationship of serum Se and thyroid carcinoma, which may be another reason for the inconsistent results of this experiment

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They can produce a temporary skin-brightening effect by reducing melanin production and oxidative stress but they dont permanently whiten skin, and results differ between individuals