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Additionally, the Neh2 structural domain contains lysine residues, which are substrates for ubiquitination and are involved in the degradation of the Nrf2 protein [16]

Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management

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Since A and B rings are fused in cis configuration, the planar structure of the steroid nucleus is curved, and it is possible to identify: a concave side, which is hydrophilic because the hydroxyl groups and the carboxyl group of the side chain, with or without the linked amino acid, are oriented towards it