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In fact, Al binds to the negatively-charged carboxyl groups of pectins, and both Al-induced ROS and free Al 3+ can disrupt the cell wall, producing modifications that could in turn reduce elasticity, due to the cleavage of polysaccharides or methyl esterification (Yang et al., 2010

Moreover, in a study using a nonobese prediabetic rat model, the increased phosphorus content in the diet, which is known to increase 2,3-DPG (21) , was associated with a reduction in hypoxia-inducible factor-1 in the perivascular adipose tissue (154)