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Preclinical Observations Findings observed in murine studies include: Endurance capacity: Increased treadmill running time and distance Mitochondrial function: Enhanced respiration and ATP production in muscle Cardiac metabolism: Improved fatty acid utilization in models of heart failure Renal function: Reduced mitochondrial dysfunction and inflammation in aging kidney models Metabolic profile: Improved glucose handling in metabolic syndrome models These results are limited to animal models using intraperitoneal injection

An ACL tear usually occurs with an abrupt directional change with the foot fixed on the ground or when the deceleration force crosses the knee

Mnchen:Elsevier GmbH, 2006

Utilizing HPLCMS/MS, metabolic intermediates in the malateaspartate shuttle, urea cycle, glucosealanine cycle and beta-alanine, aspirate, and tryptophan breakdown pathways were found to differ significantly between controls and patients with ASD