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Parkinsons disease: a dual-hit hypothesis

A small portion of cellular glutathione is in the oxidized state (GSSG), which takes on the form of a dimer connected by a disulfide bond between the cysteines of two glutathione molecules

Materials and Methods Cell Lines HEK293 cells were obtained from ATTC and maintained in DMEM with 5% fetal bovine serum and Penn/Strep antibiotics and maintained in 5% CO 2

492 Upon activation, it elicits conformational shifts in the androgen receptor, selectively modulating its interaction with coactivator and corepressor proteins present in various tissues, thereby altering the receptors capacity to modulate gene expression