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Neurochem Int 60(7):662671 Antoniades CG, Khamri W, Abeles RD, Taams LS, Triantafyllou E, Possamai LA, Bernsmeier C, Mitry RR, OBrien A, Gilroy D, Goldin R, Heneghan M, Heaton N, Jassem W, Bernal W, Vergani D, Ma Y, Quaglia A, Wendon J, Thursz M (2013) Secretory leukocyte protease inhibitor: a pivotal mediator of anti-inflammatory responses in acetaminophen induced acute liver failure

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One important reason is that DTP cells can survive under the action of chemotherapeutic drugs and enter a low proliferation state, just like embryos in diapause, thereby evading drug killing (39, 51, 52)

Nanotherapy As mentioned above, systematic treatment for BCBM is not as efficacious as it is for peripheral metastases owing to the presence of the BBB