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More importantly, oxidant enzymes including mitochondrial electron transport chain complex I, complex II, complex III, as well as SODs, xanthine oxidase (XO), NO synthases (NOS), cytochrome p 450 enzymes (CYP), NADPH oxidases (NOX) and lipoxygenase (LOX), generate O 2 radicals which are quickly converted into H 2 O 2 , OH and other radicals [26]

10.3390/antiox11112237 5 AndreouA.TrantzaS.FilippouD.SipsasN.TsiodrasS

Because ethnic skin naturally has a higher amount of melanin or pigment in the skin, it is more susceptible to hyperpigmentation

ROO primarily targets the polyunsaturated fatty acids (PUFA) found in DNA bases and cell membranes, but it also targets almost all important groups of biomolecules