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Metabolic pathway enrichment analysis revealed that CAR T cell products of LTR have significantly increased pools of TCA metabolites, nucleotide biosynthesis intermediates, sphingolipid metabolism, and intermediates in central energy metabolism, as well as significantly decreased nucleotide catabolic and tRNA metabolism intermediates, which is critical for T cell activation 10 , compared to those of STR (Fig

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We find that, in order to comply with the statutory requirements to annually review and update these payment systems and ensure that the payment policies for these systems are effective on an annual basis, we must ensure that the rule is effective no later than 1 full year after the effective date of the previous year's update (that is, January 1 of each year)