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Parkin ubiquitinates mitochondrial surface proteins, marking them for degradation via the autophagosome (117)

In the clinical trial for postmenopausal osteoporosis, patients with baseline creatinine clearance less than 30 mL/min (based on actual body weight), urine dipstick greater than or equal to 2+ protein or increase in serum creatinine of greater than 0.5 mg/dL during the screening visits were excluded

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As serum B12 levels drop below whats considered deficient, MMA levels start to increase more drastically (Clarke, 2003)