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Subgroup analyses stratified by ethnicity, source of controls and quality of evidence confirmed this finding among several subgroups, but particularly among studies considered high-quality evidence

The actual risk profile depends on the peptide, the source, the dose, and the patients overall health

Given the narrative design of this review, inclusion was based on conceptual and mechanistic relevance rather than rigid methodological scoring or quantitative pooling

Ipamorelin has a longer half-life, estimated at approximately 2 hours in preclinical models, allowing a more sustained stimulus at the GHS-R1a receptor before clearance