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Notably, Rhodiola rosea , Ginkgo biloba , and Withania somnifera (Ashwagandha) have garnered particular interest owing to their distinctive pharmacological characteristics that intersect with monoaminergic neurotransmission, neurotrophic support, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, and anti-inflammatory signalingmechanisms that are consistently implicated in the pathophysiological framework of depression

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This step commits acetyl-CoA to fatty acid synthesis for two reasons: (i) its product, malonyl-CoA, prevents the oxidation of fatty acids to mitochondria by inhibiting their entry at the level of carnitine palmitoyltransferase 1 (Fig