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Industrial facilities, mines, and toxic-waste dumps contribute to exposure, along with environmental factors that facilitate contamination, such as lack of regulation, and social problems such as poverty and income inequality [14,38]

However, challenges exist, such as the limited number of available targets

In a previous study on 12 Sprague Dawley rats given Gelam honey as much as 2.5ml/kg BW, which is equivalent to 1 tsp for adults in 8 months, can reduce levels of MDA and levels of DNA damage.33 Previous research also states that Rambutan Honey contains flavonoids and phenolic as a natural antioxidant which plays a role in reducing lipid peroxide and free radicals.9 The existence of stressful conditions can suppress the circulation of gonadotropins and steroid hormones, which will result in the disruption of the menstrual cycle

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