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For B16F10 tumour-bearing C57/6N mice, mice were treated with PBS (a), Phe-BF 3 (b), TBS&RGD@AuNPs (c), 2-fPBA&anti-CD3@AuNPs (d), mixed AuNPs (e) or mixed AuNPs + Phe-BF 3 (f) for the single therapy

Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans It makes sense, because the formation of melatonin requires a methyl group