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A 2021 review in Nature Reviews Molecular Cell Biology describes a gradual drop in tissue and cellular NAD+ across aging in rodents and humans, and links that fall to metabolic disease, cognitive decline, and sarcopenia [1]

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Those free fatty acids then enter the bloodstream and become available for oxidation, which means your body burns them for energy

What they did: Multiple preclinical models (mice, rats) evaluated the combination AOD-9604 + GLP-1 agonist (Semaglutide or Liraglutide)