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"REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity" (PDF)

When multiple circuitries break down, patients come close to a point-of-no-return in which health appears definitely lost and therapeutic interventions appear likely impossible (Lpez-Otn and Kroemer, 2021)

Gut microbiota and TMAO affect CVDs in various ways and interact with each other, and this link provides an opportunity to identify TMAO as a new therapeutic target to treat CVDs

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