neurotranmitter conjugation to glutathione Metabolism of S-Conjugates: Multiple Pathways 14 Formation of a reactive

Even after viral clearance, senescence propagates to parenchymal cells via paracrine signaling, forming a senescencerepair blockade cycle, highlighting the importance of senescent cell clearance in promoting epithelial repair

J Am Acad Dermatol 2016;74 (5)

Miller and his colleagues observed that treatment of VSMC with BaP induced reactive oxygen species (ROS) accumulation which leads to a variety of different outcomes, including activation of nuclear proteins to bind antioxidant response element/electrophilic response element (ARE/EpRE), activation of cytosolic proteins that translocate and bind ARE/EpRE, or redox sensor that interacts with cellular proteins to activate binding to ARE/EpRE

That difference can influence dosing, titration pace, and side effect patterns