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Clinical trial data recorded headache as the most frequent adverse event, occurring in a small percentage of participants

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There is no evidence from long-term use in patients with pernicious anemia that cyanocobalamin is carcinogenic

Work from David Savages group showed that PLIN1 mutations from patients with lipodystrophies, which lack the C-terminus, fail to stabilize ABHD5 on LDs, resulting in greater basal lipolysis (137) and likely explains why these patients are unable to sequester FAs into TAGs