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Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice

Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress

On one hand, 16-OHE activates ER, leading to upregulation of nicotinamide adenine dinucleotide phosphate oxidase (Nox)1 and Nox4 expression and increases reactive oxygen species (ROS) production, mainly superoxide anion and hydrogen peroxide, mediated by these enzymes

By binding to specific receptors, TNF- initiates signal cascades, activating nuclear factor-kappa B (NF-B) to regulate inflammatory responses, and triggers cell activation, differentiation, cytokine production, and apoptosis, thus contributing to fibrosis progression