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The CysLT1 receptor is widely expressed with highest levels in spleen and peripheral blood leukocytes

Piazza C, Lancini D, Tomasoni M, Zafereo ME , Poorten VV, Hanna E, Mkitie AA, Fernandez-Alvarez V, Kowalski LP, Chiesa-Estomba C, Ferlito A

J Biomed Sci 25(1):111 Murray BO, Dawson RA, Alsharaf LM, Winter JA (2020) Protective effects of Helicobacter pylori membrane vesicles against stress and antimicrobial agents

Since the 1990s, clinical research has been carried out by a study group on the Ministry of Health, Labour and Welfare, suggested that ultrahigh-dose mecobalamin, which is respectively 50 and 100 times the approved dosage of Methycobal, could have a clinical effect in ALS, and Eisai then conducted the Phase II/III clinical trial (Study 761) from 2006