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Doctors decide if someone needs B12 shots based on their health and how much B12 they have

The increased demands of growing tumors in nutrients and oxygen triggers the formation of new blood vessels, a process called angiogenesis

Long-term safety data from decades of cosmetic use provides reassurance - no pattern of delayed toxicity, cumulative adverse effects, or serious safety signals has emerged despite widespread and prolonged use

Setting realistic goals: Define specific objectives (pain reduction, return to specific activities, healing verified on imaging) rather than vague "feel better." Understand realistic timeline (weeks for soft tissue, months for bone, months to years for cartilage) preventing premature disappointment