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Total glutathione concentration in the ER reaches millimolar ranges providing an exceptionally high buffering capacity against oxidizing or reducing imbalances [9, 11, 12]

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SASP contains multiple pro-inflammatory [interleukin (IL) IL-1, IL-1, IL-6, IL-8, IL-18, high-mobility group protein B1 (HMGB-1), macrophage inflammatory protein (MIP)-1a, MIP-3a, granulocyte-macrophage colony-stimulating factor, and tumour necrosis factor (TNF)-], 1,15,41,42 extracellular matrix remodelling [matrix metalloproteinase (MMP)-1, -2, -3, -7, -8, -9, -10, -12, -13, and -14] 1,4346 and coagulation-modulating factors (tissue factor pathway inhibitor, calumenin, plasminogen activator inhibitor 1 (PAI-1), PAI-2, SERPINE 2, and SERPINE B6)