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Additionally, Mitochondrial dysfunction leads to impaired calcium buffering, resulting in cytosolic Ca 2+ overload

This includes enhancing the release and dissolution of active components, reducing or transforming toxic substances, and enabling tissue-targeted delivery through adjuvants

157 An NAFLD mouse model induced by a high-fat, high-sugar diet for 6 months exhibits hypercholesterolemia, glucose intolerance, and hyperinsulinemia, accompanied by severe hepatic macro- and microvesicular steatosis and human-like pericellular fibrosis, along with hepatic stellate cell activation, CD68 + macrophage infiltration, and elevated hepatic pro-inflammatory factors p65-NF-B, IL-6, and TNF- protein levels